Identifying optimal drugs and dosage based on genetics

While Pharmacogenomics may be a new buzzword, it’s one worth knowing about. With a simple genetic test, healthcare professionals open a world of information about their patient. Insight into which drugs will have optimal results, what dosage will be most effective, and whether a medication will be beneficial at all for a patient is a huge step toward streamlining the efficacy of medical care.


We represent a commercial stage molecular diagnostics company specializing in the field of pharmacogenomics, or PGx. Our PGx product testing portfolio enables personalized therapeutic decisions for patients suffering from some of the most prevalent clinical conditions in the United States, including cardiovascular disease, neuropsychiatric disorders and pain. Our lab’s proprietary algorithm-based bioinformatic platform and PGx product testing portfolio assist healthcare providers in identifying optimal drugs for their patients and dosing guidelines. Based on a patient’s genetic make-up, current prescription regimen and other key factors, healthcare providers are able to make timely and evidence-based decisions. This can reduce the overall cost of patient care by reducing adverse events, optimizing patients’ overall therapeutic regimen and helping to achieve a faster therapeutic response.

In 2013, the U.S. healthcare system spent in excess of $260 billion on prescription drugs and that amount is expected to exceed $450 billion in 2022.

In 2013, the U.S. healthcare system spent in excess of $260 billion on prescription drugs and that amount is expected to exceed $450 billion in 2022.

Nearly 50% of the U.S. population, and almost 90% of people 65 years and over (or approximately 36 million patients), take at least one prescription drug and more than 10% of the U.S. population, and almost 40% of people 65 years and over (or approximately 16 million patients), take five or more prescription drugs, which we refer to as polypharmacy.

We estimate that the overall potential market opportunity for Advanced Genomics is greater than 150 million patients in the United States. This is representative of the number of people that take at least one prescription drug, and includes the more than 30 million people who are polypharmacy.

We believe there are significant health concerns and unnecessary costs associated with the trial-and-error manner in which physicians prescribe drugs, without prior knowledge of an individual patient’s genetic profile.

There are an estimated 100,000 deaths and more than two million serious adverse reactions attributable to prescription drug use in the United States each year, at a cost to the healthcare industry that exceeds $136 billion annually.

It has been estimated that genetics can account for up to 95% of variability in drug disposition and effects and as much as 40-60% of adverse drug reactions.

We believe Advanced Genomics can improve clinical outcomes and reduce the overall cost of prescription drugs by enabling better drug selection, earlier favorable results and lower occurrence of adverse events.

The lab is designed to provide a comprehensive PGx test offering to best meet the needs of our target customers such as long-term and post-acute care facilities, government facilities, integrated delivery networks, or IDNs, and managed care organizations.

These institutional healthcare providers require broad PGx testing capabilities to manage a large and diverse patient population, with patients often suffering from multiple clinical conditions.

These customers often operate under fixed-fee-per-patient or fixed-fee-per-procedure arrangements and are searching for ways to improve clinical outcomes at the lowest possible cost.

In addition, the lab addresses the needs of physicians across multiple specialties, such as cardiologists, general practitioners, obstetricians and neurologists.

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